SAN DIEGO--(BUSINESS WIRE)--Nov 26. 2007 - Nereus Pharmaceuticals,Inc. a pioneer in the use of marine microbial sources for thediscovery and development of cancer therapeutics and itscollaborators ordain present preclinical study results involving itscancer drug candidate NPI-0052 at the 49th Annual Meeting of theAmerican Society of Hematology (ASH) in Atlanta. Georgia December8-11. Two oral presentations and two posters ordain highlight thenovel mechanism high potency and synergistic anti-tumor activityof the small molecule proteasome inhibitor NPI-0052 in combinationwith bortezomib (Velcade(TM). Millennium Pharmaceuticals) inseveral tumor models for multiple myeloma. Waldenstrom'smacroglobulinemia and B-non-Hodgkin's lymphoma. The findingsillustrate how the two proteasome inhibitors affect the aim toproduce significantly different efficacy and toxicologycharacteristics in preclinical studies. In addition early safetydata from Nereus' arrange I dose escalation trial of NPI-0052 inpatients with lymphomas and solid tumors will be published in ASH'sabstract air of daub.
In addition to the preclinical and clinical data for NPI-0052 tobe presented at ASH a cover co-authored by Nereus' ChiefTechnology Officer and Scientific Co-founder Michael Palladino,Ph. D with collaborators from the Dana-Farber Cancer initiate hasbeen accepted for publication in a future edition of ASH's Blood. The investigate again demonstrates that combining NPI-0052 andbortezomib induces synergistic anti-multiple myeloma activity in anumber of preclinical models.
Aldo Roccaro. Xavier Leleu. Antonio Sacco. Xiaoying Jia,Anne-Sophie Moreau. Hai Ngo. Abdelkareem Azab. Feda Azab. EvdoxiaHatjiharissi. Steven Treon. Teru Hideshima. Michael Palladino,Kenneth Anderson. Dharminder Chuahan. Irene Ghobrial. Dana-FarberCancer initiate. Boston. MA. Nereus Pharmaceuticals. San Diego,CA.
Dharminder Chauhan. Ajita Singh. Mohan Brahmandam. Klaus Podar,Teru Hideshima. Robert Schlossman. Paul Richardson. Nikhil Munshi,Michael Palladino. Kenneth C. Anderson. Dana-Farber CancerInstitute. Boston. MA; Nereus Pharmaceuticals. San Diego. CA.
#667 - Targeting Cdk4/6 in combination therapy overcomesproteasome inhibitor resistance in multiple myeloma throughsynergistic mitochondria depolarization
Xiangao Huang. Tracey Louie. Maurizio Di Liberto. Jun Rice,David Jayabalan. Kang Zhang. Michael Palladino. Isan Chen. PeterToogood. Ruben Niesvizky. Malcolm A. S. Moore. Selina Chen-Kiang. Departments of Pathology and Medicine and have Program inImmunology and Microbial Pathogenesis. Weill Cornell MedicalCollege. New York. NY. Memorial Sloan-Kettering Cancer Center. NewYork. NY. Nereus Pharmaceuticals. San Diego. CA. Pfizer GlobalResearch and Development. San Diego. CA and Ann Arbor. MI.
Stavroula Baritaki. Kam Yeung. Devasis Chatterjee. MichelPalladino. Benjamin Bonavida. Departments of Microbiology,Immunology and Molecular Genetics. David Geffen School of care for,Johnson Comprehensive Cancer bear on. UCLA. Los Angeles. CA;Biochemistry and Molecular Biology. Medical College of Ohio,Toledo. OH; care for. Brown University and Rhode Island Hospital,Providence. RI; Nereus Pharmaceuticals. San Diego. CA.
Razelle Kurzrock. Paul Hamlin. Anas Younes. David Hong. MichaelGordon. Matthew A. Spear. Michael A. Palladino. G. Kenneth Lloyd,Angie M. Longenecker. Saskia T. C. Neuteboom. Gillian F. Cropp,Alison Hannah. sing Aghajanian (Intr by Alison L. Hannah). M. D. Anderson Cancer bear on. Houston. TX. Memorial Sloan-KetteringCancer Center. New York. NY. Premiere Oncology of Arizona,Scottsdale. AZ. Nereus Pharmaceuticals. San Diego. CA.
Nereus' novel small molecule proteasome inhibitor NPI-0052 isin three Phase I trials at world-class cancer centers in the U. S.,Australia and Europe for solid tumors lymphomas leukemias andmultiple myeloma. Clinical trial sites consider the M. D. AndersonCancer Center the Memorial Sloan-Kettering Cancer bear on theDana-Farber Cancer Institute. Ohio State University. Roswell ParkCancer Institute and University of Chicago. Preclinical studiesindicate that this next generation compound may be superior toother proteasome inhibitors with broader aim inhibition fasteronset and longer duration of action higher potency oral andintravenous availability and activity against myeloma cellsresistant to Velcade. Thalomid(R) (thalidomide. CelgeneCorporation). Revlimid(R) (lenalidomide. Celgene Corporation) andsteroid therapy. NPI-0052 was derived from a marine-obligategram-positive actinomycete (Salinispora tropica).
Nereus Pharmaceuticals pursues novel sources of chemicaldiversity to sight and develop new therapeutics. Using itsunmatched expertise in marine microbiology to determine uniquebiologically active compounds the Company has two oncology drugcandidates in Phase I clinical trials. NPI-2358 a tumor vasculardisrupting agent is being evaluated in patients with solid tumorsand lymphomas and the proteasome inhibitor NPI-0052 is beingdeveloped in patients with solid tumors lymphomas leukemias andmultiple myeloma. The Company's discovery portfolio also includespotential drug candidates for cancer infectious diseases andinflammation. For more information visit www nereuspharm com.
Nereus Pharmaceuticals is a registered trademark of NereusPharmaceuticals. Inc. All other product and affiliate names may beregistered trademark or trademarks of their respective owners.
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